1-Bromo-3-chloropropane → 1-(3-Chloropropoxy)-4-iodobenzene

Participants

Reaction Steps

1-Bromo-3-chloropropane (21.4 g, 136 mmol) and potassium carbonate (30 g, 217 mmol) were added to an acetone (300 mL) solution of 4-iodophenol (20 g, 90.9 mmol), and stirred under reflux for 20 hours. The reaction mixture was cooled to room temperature, filtered, and the filtrate was concentrated under reduced pressure to obtain the entitled compound (30 g, 100%).

Provenance & Evidence