2,6-Difluoropyridine-4-boronic acid → 5-Fluoro-3-methyl-benzo[b]thiophene-2-sulfonic acid[4-(2,6-difluoro-pyridin-4-yl)-2-trifluoromethyl-phenyl]-amide

Participants

Reaction Steps

This compound was prepared in analogy to Example 2 starting from 5-fluoro-3-methyl-benzo[b]thiophene-2-sulfonic acid(4-bromo-2-trifluoromethyl-phenyl)-amide (0.12 g) and 2,6-difluoropyridine-4-boronic acid (0.063 g) in 1,2-dimethoxyethane (1.5 ml), ethanol (0.32 ml) and 2 M aqueous sodium carbonate solution (1.0 ml) with tetrakis(triphenylphosphine)palladium (0.055 g) to obtain the title compound (0.055 g) as a brownish solid. MS (ISP): 520.2 (M+NH4)+

Provenance & Evidence