(6-Methoxypyridin-3-yl)boronic acid → 5-Fluoro-3-methyl-benzo[b]thiophene-2-sulfonic acid [4-(6-methoxy-pyridin-3-yl)-2-trifluoromethyl-phenyl]-amide

Participants

Reaction Steps

This compound was prepared in analogy to Example 2 starting from 5-fluoro-3-methyl-benzo[b]thiophene-2-sulfonic acid(4-bromo-2-trifluoromethyl-phenyl)-amide (0.10 g) and 2-methoxy-5-pyridineboronic acid (0.065 g) in 1,2-dimethoxyethane (1.5 ml), ethanol (0.32 ml) and 2 M aqueous sodium carbonate solution (0.8 ml) with tetrakis(triphenylphosphine)palladium (0.012 g) to obtain the title compound (0.081 g) as a colorless solid. MS (ISP): 497.3 (M+H)+

Provenance & Evidence