(Pyrimidin-5-yl)boronic acid → 5-Fluoro-3-methyl-benzo[b]thiophene-2-sulfonic acid (4-pyrimidin-5-yl-2-trifluoromethyl-phenyl)-amide

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Reaction Steps

This compound was prepared in analogy to Example 2 starting from 5-fluoro-3-methyl-benzo[b]thiophene-2-sulfonic acid(4-bromo-2-trifluoromethyl-phenyl)-amide (0.10 g) and pyrimidine-5-boronic acid (0.053 g) in 1,2-dimethoxyethane (1.5 ml), ethanol (0.32 ml) and 2 M aqueous sodium carbonate solution (0.8 ml) with tetrakis(triphenylphosphine)palladium (0.012 g) to obtain the title compound (0.045 g) as a colorless solid. MS (ISN): 466.1 (M−H)−

Provenance & Evidence