HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-(trifluoromethoxy)aniline → 5-Fluoro-3-methyl-benzo[b]thiophene-2-sulfonic acid (4-bromo-2-trifluoromethoxy-phenyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-(trifluoromethoxy)aniline | HCID 737382 | — |
| Reactant | 5-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride | HCID 2774586 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 5-Fluoro-3-methyl-benzo[b]thiophene-2-sulfonic acid (4-bromo-2-trifluoromethoxy-phenyl)-amide | HCID 24966318 | 24.8% |
Reaction Steps
This compound was prepared in analogy to Example 1, starting from 4-bromo-2-(trifluoromethoxy)aniline (CAS: 175278-09-8, 2.82 g) and 5-fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride (0.265 g) in pyridine (2.0 ml) for 18 h to obtain the desired compound (0.12 g) as a colorless foam. MS (ISP): 501.0, 503.0 (M+NH4)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158655B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-88085743a64d4b798af3b946a8a918b4 |
| Source note | uspto-grants-2012_04 |