Benzylamine → HCID 59759974, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-(4-chloro-3-methanesulfonyl-phenyl)-pyridin (5.5 g) in benzylamine (23 ml) was heated to 160° C. for 4 h, concentrated under high vacuum. The residue was quenched with ice/water and extracted with ethyl acetate. The organic layers were washed, dried and concentrated; the residue was chromatographed on silica gel with heptane/ethyl acetate. The compound containing fractions were evaporated, and the residue crystallized from methanol/ether to obtain the desired compound (5.75 g) as an off-white solid. MS (ISP): 339.1 (M+H)+

Provenance & Evidence