Pyridine → HCID 24966675, compound

HRID 1693122Notes

Reaction equation

HRID 1693122 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH:8]=[CH:7][C:6]=1[NH2:17])(=[O:4])=[O:3].N1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>ClCCl>[CH3:1][S:2]([C:5]1[CH:10]=[C:9]([C:11]2[CH:12]=[CH:13][N:14]=[CH:15][CH:16]=2)[CH:8]=[CH:7][C:6]=1[NH:17][S:2]([C:19]1[CH:9]=[CH:10][C:5]2[C:21](=[CH:22][CH:23]=[CH:7][CH:6]=2)[CH:20]=1)(=[O:4])=[O:3])(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 1049PyridineHCID 59759965HCID 59759965, compound

Product 1

HCID 24966675HCID 24966675, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
70 °C

Procedure

To a solution of 2-methanesulfonyl-4-pyridin-4-yl-phenylamine (cf. Example 20c, 0.046 g) in pyridine (0.5 ml) was added naphthalene-2-sulfochloride (0.051 g). The reaction mixture was stirred at 70° C. for 6 h, diluted with dichloromethane and chromatographed on silica gel using dichloromethane/methanol/ammonia to obtain the title compound (0.025 g) as an off-white solid. MS (ISP): 439.1 (M+H)+

Workup

  1. customchromatographed on silica gel

Sources & evidence

ORD record
ord-0c19c1bd978942e6a0b1d00f9002949f
Source dataset
uspto-grants-2012_04
Patent number
US08158655B2

Reaction notes

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