HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1693127Generated: November 2, 2026
4-(Pyridin-4-yl)aniline → 2-(4-Pyridin-4-yl-phenylsulfamoyl)-indole-1-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/1693127
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-(Pyridin-4-yl)aniline | HCID 1512654 | — |
| Reactant | tert-butyl 2-(chlorosulfonyl)-1H-indole-1-carboxylate | HCID 53439194 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 2-(4-Pyridin-4-yl-phenylsulfamoyl)-indole-1-carboxylic acid tert-butyl ester | HCID 59759971 | 49.1% |
Reaction Steps
To a solution of (4-pyridine-4-yl)aniline (CAS: 13296-04-3, 0.054 g) and 2-chlorosulfonyl-indole-1-carboxylic acid tert-butyl ester (0.120 g; cf. Shankar, Bandarpalle B.; Gilbert, Eric; Rizvi, Razia K.; Huang, Chunli; Kozlowski, Joseph A.; McCombie, Stuart; Shih, Neng-Yang. WO 2006002133) in 1,2-dichlorethane (5.0 ml) was added DMAP (0.047 g). The reaction mixture was stirred at 50° C. for 3 h and chromatographed on silica gel using dichloromethanelethyl acetate as eluent to obtain the desired compound (0.070 g) as a colorless powder. MS (ISP): 450.4 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08158655B2 |
|---|
| Source dataset | uspto-grants-2012_04 |
|---|
| ORD ID | ord-6c6d3ac094cb49f498f44139d485c99d |
|---|
| Source note | uspto-grants-2012_04 |
|---|
