Hydrogen chloride-ethyl acetate → 5-Fluoro-1-methyl-1H-indole-2-sulfonic acid (2-methanesulfonyl-4-piperidin-4-yl-phenyl)-amide hydrochloride

関与物質

反応手順

A solution of 4-[4-(5-fluoro-1-methyl-1H-indole-2-sulfonylamino)-3-methanesulfonyl-phenyl]-piperidine-1-carboxylic acid tert-butyl ester (0.019 g) was treated with 2.5 N HCl/ethyl acetate (2.5 ml). The reaction mixture was stirred at rt for 3 h, then ether (20 ml) was added. The precipitate was collected, washed with ether and dried under high vacuum over P2O5 to produce the title compound (0.014 g) as an off-white amorphous powder. MS (ISN): 464.0 (M−H)−

情報源と証拠