4-Bromo-2-(trifluoromethyl)aniline → 5-Fluoro-3-isobutyl-benzo[b]thiophene-2-sulfonic acid(4-bromo-2-trifluoromethyl-phenyl)-amide

HRID 1693139Notes

Reaction equation

HRID 1693139 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]2[S:6][C:7]([S:13](Cl)(=[O:15])=[O:14])=[C:8]([CH2:9][CH:10]([CH3:12])[CH3:11])[C:4]=2[CH:3]=1.[NH2:19][C:20]1[CH:25]=[CH:24][C:23]([Br:26])=[CH:22][C:21]=1[C:27]([F:30])([F:29])[F:28]>N1C=CC=CC=1>[Br:26][C:23]1[CH:24]=[CH:25][C:20]([NH:19][S:13]([C:7]2[S:6][C:5]3[CH:17]=[CH:18][C:2]([F:1])=[CH:3][C:4]=3[C:8]=2[CH2:9][CH:10]([CH3:12])[CH3:11])(=[O:15])=[O:14])=[C:21]([C:27]([F:28])([F:29])[F:30])[CH:22]=1

Participants

4

Reactant 2

HCID 679604-Bromo-2-(trifluoromethyl)anilineHCID 597599685-Fluoro-3-isobutyl-benzo[b]thiophene-2-sulfonyl chloride

Product 1

HCID 597599705-Fluoro-3-isobutyl-benzo[b]thiophene-2-sulfonic acid(4-bromo-2-trifluoromethyl-phenyl)-amide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

This compound was prepared in analogy to Example 1 starting from 5-fluoro-3-isobutyl-benzo[b]thiophene-2-sulfonyl chloride (044 g), 2-amino-5-bromobenzotrifluoride (3.44 g) in pyridine (5 ml) for 18 h at rt to obtain the desired compound (0.24 g) as a colorless solid. MS (ISN): 508.2, 510.3 (M−H)−

Sources & evidence

ORD record
ord-4eb1c68c8ee14d91b5d0e9e0749c0535
Source dataset
uspto-grants-2012_04
Patent number
US08158655B2

Reaction notes

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