HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5-(1-methyl-1H-pyrazol-4-yl)pyridine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl 5-(1-methyl-1H-pyrazol-4-yl)-pyridine-2-carboxylate | HCID 57827379 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(1-methyl-1H-pyrazol-4-yl)pyridine-2-carboxylic acid | HCID 57827465 | 267.8% |
Reaction Steps
TFA (1 mL) was added to a solution of tert-butyl 5-(1-methyl-1H-pyrazol-4-yl)-pyridine-2-carboxylate (81 mg) in dichloromethane (4 mL), and the mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure to obtain a crude product of the title compound (170 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158620B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-f39fe0e01d2e464b89cc77eef80e53e9 |
| Source note | uspto-grants-2012_04 |