Hydrochloric Acid → HCID 44476317, compound

Participants

Reaction Steps

A mixture composed of di-tert-butyl {7-cyano-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7,8-dihydro-2H-6-thia-1,2,3,5-tetraazaacenaphthylen-4-yl}imidodicarbonate of Step 4) of Example 3 (30 mg) and concentrated hydrochloric acid (1 mL) was stirred at room temperature for 1.5 hours. The reaction mixture was diluted with water and neutralized with a saturated sodium bicarbonate solution. The precipitate was collected by filtration and sequentially washed with a saturated sodium bicarbonate solution and water. Then, the resulting solid was dried to obtain the title compound (18.5 mg, 91%).

Provenance & Evidence