Dimethyl Sulfoxide → HCID 67280305, compound

Participants

Reaction Steps

A mixture composed of di-tert-butyl {8-hydroxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-2,7,8,9-tetrahydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl}imidodicarbonate of Example 32 (778 mg), dimethyl sulfoxide (10 mL) and acetic anhydride (1 mL) was stirred in a nitrogen atmosphere at room temperature for 12 hours. After confirming that the raw material disappeared, the reaction mixture was diluted with ethyl acetate and sequentially washed with water and brine. The organic layer was dried over anhydrous sodium sulfate and filtered. Then, the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate-hexane) to obtain the title compound (507 mg, 61%) as an oil.

Provenance & Evidence