Potassium Carbonate → HCID 67279997, compound

Participants

Reaction Steps

A mixture of 4-[bis(tert-butoxycarbonyl)amino]-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl acetate of Example 39 (507 mg), methanol (12 mL) and potassium carbonate (57 mg) was stirred under cooling in an ice bath for 30 minutes. After confirming that the raw material disappeared, a saturated ammonium chloride solution was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with brine, and then dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate-hexane) to obtain the title compound (430 mg, 91%) as an oil.

Provenance & Evidence