Tetrahydrofuran → HCID 86641347, compound

Participants

Reaction Steps

A mixture composed of the above tert-butyl {8-(2-azidoethyl)-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl}carbamate (31 mg), triphenylphosphine (23 mg), tetrahydrofuran (0.9 ml) and water (0.1 ml) was stirred at room temperature for five hours. A 0.2 N sodium hydroxide solution (2.5 ml) was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was dried over sodium sulfate and filtered, and then the solvent in the filtrate was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (NH silica used, ethyl acetate-chloroform) to obtain the title compound (17 mg) as an oil.

Provenance & Evidence