Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 58201194, compound

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Reaction Steps

The above di-tert-butyl {4-chloro-3-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl}imidodicarbonate (22 g) was dissolved in methanol (400 ml). Pyridinium p-toluenesulfonate (10 g) was added and the mixture was stirred at room temperature for 16 hours. The reaction solution was concentrated, and water (100 ml) was added to the resulting residue, followed by extraction with ethyl acetate (500 ml). The organic layer was washed with brine, and then dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to obtain the title compound (19.5 g, 95%) as an amorphous.

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