Ethanol hexane → HCID 86641353, compound

Participants

Reaction Steps

Di-tert-butyl {8-[cyclopropyl(trifluoroacetyl)amino]-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-2,7,8,9-tetrahydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl}imidodicarbonate (1.0 g) was dissolved in ethanol (20 ml) and optically resolved by AD column 50×500 mm (15% ethanol/n-hexane 50.0 ml/min). This operation was repeated three times to obtain di-tert-butyl {8-(S)-[cyclopropyl(trifluoroacetyl)amino]-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-2,7,8,9-tetrahydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl}imidodicarbonate (RT=70 min) (1.3 g, 43%) and di-tert-butyl {8-(R)-[cyclopropyl(trifluoroacetyl)amino]-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-2,7,8,9-tetrahydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl}imidodicarbonate (RT=130 min) (1.0 g, 33%).

Provenance & Evidence