Ethanol → HCID 67280049, compound

Participants

Reaction Steps

4-[Bis(tert-butoxycarbonyl)amino]-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl trifluoromethanesulfonate (25 mg) was dissolved in ethanol (2 ml). Triethylamine (6 μl) and bis(triphenylphosphine)palladium (II) dichloride (2.5 mg) were added at room temperature, and the mixture was stirred in a carbon monoxide atmosphere at 40° C. for three hours. The reaction solution was concentrated, and the resulting residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain the title compound as an oil (14 mg, 62%).

Provenance & Evidence