4-Piperidinecarboxylic acid → 4-Piperidinecarboxylic acid, methyl ester, hydrochloride (1:1)

HRID 1693394Notes

Reaction equation

HRID 1693394 reaction equation
[C:1]([Cl:4])(=O)C.[NH:5]1[CH2:10][CH2:9][CH:8]([C:11]([OH:13])=[O:12])[CH2:7][CH2:6]1>CO>[ClH:4].[CH3:1][O:12][C:11]([CH:8]1[CH2:9][CH2:10][NH:5][CH2:6][CH2:7]1)=[O:13]

Participants

4

Reactant 2

HCID 37734-Piperidinecarboxylic acidHCID 6367Acetyl chloride

Product 1

HCID 187838294-Piperidinecarboxylic acid, methyl ester, hydrochloride (1:1)

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a cooled solution of anhydrous methanol (100 mL) was added acetyl chloride (7.1 mL, 0.1 mol) and the solution stirred for 75 min. Piperidine-4-carboxylic acid (150 mg, 1.16 mmol) was dissolved in the prepared solution (10 mL) and the reaction stirred for 16 h. The solvent was removed in vacuo to give the title compound as its hydrochloride salt. m/z (ES+)=144.12 [M+H]+.

Workup

  1. stirringthe reaction stirred for 16 h
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-b503a1cb3e3146e7b60742f710db1436
Source dataset
uspto-grants-2012_04
Patent number
US08158622B2

Reaction notes

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