Sodium Carbonate → HCID 57898018, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-(4-chloro-phenyl)-2-(4-iodo-phenyl)-9-phenyl-1,9-dihydro-purin-6-one (20 mg, 0.038 mmol), 3-thiophene boronic acid (9.7 mg, 0.076 mmol) and tetrakis(triphenylphosphine) palladium (4.4 mg, 0.0038 mmol) in 1 mL of toluene is added 2.0 M Na2CO3 solution (200 μL). The reaction mixture is heated at 170° C. on the microwave oven for 20 min. After cooled down, the resulting solution is concentrated and purified with HPLC. 1H NMR (CDCl3) δ(ppm) 8.12 (s, 1H), 7.71 (d, 2H), 7.57 (t, 2H), 7.47 (m, 4H), 7.38 (m, 1H), 7.33 (m, 5H), 7.14 (d, 2H); HPLC-MS calculated for C27H17ClN4OS (M+H+): 481.0. Found 481.0.

Provenance & Evidence