Phosphorus oxychloride → HCID 57898179, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-7-oxo-3-phenyl-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl]-acetamide (10.0 mg, 0.020 mmol) and POCl3 (0.5 mL) is heated at 100° C. for 30 minutes. Upon completion, excess POCl3 is removed under reduced pressure. The residue is purified by preparative LC/MS to provide the title compound; HPLC-MS calculated for C28H22ClN5O (M+H+) 480.1. Found 480.1.

Provenance & Evidence