反应详情

To a solution of 6-[4-(2-butoxy-vinyl)-phenyl]-5-(4-chloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (5 mg, 0.01 mmol) in EtOH (1 mL) is added Pd/C (2 mg). The system is degassed by alternately applying vacuum and H2 for 3 times. The mixture is then stirred at room temperature under H2 for 24 h. After removing the catalyst by filtration, the filtrate is concentrated and purified by flash column chromatography (silica gel, 0˜30% EtOAc/hexane) to provide the title compound as white solid (3.5 mg, 69%). HPLC-MS calculated C29H25ClN4O2 (M+1+): 497.2. Found: 497.2

1. customThe system is degassed
2. customAfter removing the catalyst
3. filtrationby filtration
4. concentrationthe filtrate is concentrated
5. custompurified by flash column chromatography (silica gel, 0˜30% EtOAc/hexane)