Hydrazine hydrate (1:1) → 3-Chloro-6-hydrazinopyridazine

Participants

Reaction Conditions

Reaction Steps

To a solution of 3,6-dichloro-pyridazine (500 mg, 3.36 mmol) in EtOH (6 mL) is added hydrazine hydrate (840 mg, 16.8 mini). The mixture is heated at 80° C. for 14 h and then cooled downed to room temperature. The solvent is removed under vacuum and the residue is triturated with water (2 mL), filtered off and dried to afford 6-chloro-3-pyridazinyl-hydrazine (280 mg, 58%) as white solid. HPLC-MS calculated C4H5ClN4 (M+1+): 145.0. Found: 145.0.

Provenance & Evidence