Chloropyrazine → 5-(4-Chloro-phenyl)-1-phenyl-6-(4-pyrazin-2-yl-phenyl)-1,5-dihydro-pyrazolo(3,4-d)pyrimidin-4-one

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Reaction Conditions

Reaction Steps

5-(4-Chloro-phenyl)-1-phenyl-6-(4-pyrazin-2-yl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one is prepared from 5-(4-chloro-phenyl)-1-phenyl-6-[4-(4,4,5,5-tetramethyl [1,3,2]dioxaborolan-2-yl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one and 2-chloro-pyrazine by using the method described in example 338 except that the reaction mixture is stirred at 100° C. for 14 hours: 1H NMR (CDCl3) δ (ppm) 9.02(d, 1H), 8.67(t, 1H), 8.55(d, 1H), 8.35(s, 1H), 8.15 (d, 2H), 7.95(d, 2H), 7.51(m, 4H), 7.37 (t, 1H), 7.33(d, 2H), 7.14(d, 2H). HPLC-MS calculated C27H17ClN6O (M+1+): 477.1. Found: 477.1.

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