HCID 67282126, compound → HCID 57897836, compound

Participants

Reaction Steps

A solution of N-[2-biphenyl-4-yl-1-(4-chloro-phenyl)-6-oxo-9-phenyl-6,9-dihydro-1H-purin-8-ylmethyl]-N-(4-methoxy-benzyl)-methanesulfonamide (18 mg, 0.026 mmol) in TFA (1 mL) was heated at 90° C. in a sealed tube for 12 h. The reaction mixture was concentrated in vacuo and the resulting crude oil was purified by flash chromatography (silica, 5% MeOH/CH2Cl2) to give the title compound Ar-[2-biphenyl-4-yl-1-(4-chloro-phenyl)-6-oxo-9-phenyl-6,9-dihydro-1H-purin-8-ylmethyl]-methanesulfonamide as a white solid. 1H NMR (CDCl3) δ (ppm) 7.64 7.54 (m, 3H), 7.51 7.45 (m, 4H), 7.44 7.38 (m, 4H), 7.37 7.30 (m, 4H), 7.28 (s, 1H), 7.13 (d, 2H), 5.92 (br s, 1H), 4.48 (s, 2H), 2.99 (s, 3H); HPLC-MS calculated for C31H24ClN5O3S (M+H+): 582.1. Found 582.1.

Provenance & Evidence