2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-{1-[4-(3,4-Dichloro-phenyl)-6-methyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-pyrimidin-2-ylamine

HRID 169366Notes

Reaction equation

HRID 169366 reaction equation
[Br:1][c:2]1[n:3][cH:4][n:5](-[c:7]2[n:8][c:9]([CH3:21])[cH:10][c:11](-[c:13]3[cH:14][c:15]([Cl:20])[c:16]([Cl:19])[cH:17][cH:18]3)[n:12]2)[cH:6]1.[NH2:22][c:23]1[n:24][cH:25][c:26]([B:29]2[O:30][C:31]([CH3:32])([CH3:33])[C:34]([CH3:35])([CH3:36])[O:37]2)[cH:27][n:28]1>>[c:2]1(-[c:26]2[cH:25][n:24][c:23]([NH2:22])[n:28][cH:27]2)[n:3][cH:4][n:5](-[c:7]2[n:8][c:9]([CH3:21])[cH:10][c:11](-[c:13]3[cH:14][c:15]([Cl:20])[c:16]([Cl:19])[cH:17][cH:18]3)[n:12]2)[cH:6]1

Participants

3

Reactant 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol esterHCID 574687752-(4-Bromo-imidazol-1-yl)-4-(3,4-dichlorophenyl)-6-methyl-pyrimidine

Product 1

HCID 602094145-{1-[4-(3,4-Dichloro-phenyl)-6-methyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-pyrimidin-2-ylamine

Sources & evidence

ORD record
ord-43948fb9dfe54bc985cd0c6f4482e6d1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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