HCID 57537593, compound → HCID 57537533, compound

Participants

Reaction Conditions

Reaction Steps

2-{[5-Bromo-3-(2-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-methyl-amino}-ethanol (10 mg, 0.0197 mmol) was dissolved in a solution of trifluoroacetic acid (1 mL) and dichloromethane (1 mL) and stirred at 23° C. for 1.5 hours. The solvent was evaporated and the resulting oil was dissolved in 1 mL DMSO and 100 μL ethylenediamine and purified by mass triggered reverse phase HPLC to afford 2-{[5-Bromo-3-(2-methoxy-phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-methyl-amino}-ethanol (1.1 mg, 0.00266, 13% yield). 1H-NMR [500 MHz, d6-DMSO] δ: 8.14 (s, 1H), 7.31 (m, 1H), 7.27 (s, 1H) 7.21 (dd, 1H), 7.02 (d, 1H), 6.96, (td, 1H), 6.67, (s, 5H), 3.14 (t, 2H), 2.75 (s, 4H); MS [MH+] m/z: 376, 378.

Provenance & Evidence