Sodium borohydride → HCID 57537679, compound

Participants

Reaction Steps

A solution of {3-[4-chloro-3-(2-fluoro-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-phenyl}-oxazol-2-yl-methanone (22 mg, 0.040 mmol) in MeOH (0.25 mL) was added to a cold suspension (0° C.) of NaBH4 (1.59 mg, 0.042 mmol) in MeOH (0.25 mL). After 1 h, the mixture was quenched by addition of saturated ammonium chloride and the solution was concentrated to a solid. The residue was triturated with ethyl acetate to afford {3-[4-chloro-3-(2-fluoro-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-phenyl}-oxazol-2-yl-methanol (16 mg, 72.82%). MS: m/z 550 (M+H+).

Provenance & Evidence