Trifluoroacetic acid → HCID 57537673, compound

Participants

Reaction Steps

{3-[4-Chloro-3-(2-fluoro-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-phenyl}-oxazol-2-yl-methanol (0.040 mmol) was treated with 1 mL neat TFA. After 1 h, the TFA was removed in vacuo. The residue was treated with ethylene diamine (0.5 mL) and THF (1 mL) for 20 min. The mixture was concentrated and purified by preparative LCMS to afford {3-[4-chloro-3-(2-fluoro-phenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-phenyl}-oxazol-2-yl-methanol (2.7 mg, 16%) MS: m/z 420 (M+H+). 1H NMR (500 MHz, DMSO-d6) δ 5.88 (d, 1H), 6.48 (d, 1H), 7.15 (d, 1H), 7.23 (m, 2H), 7.38-7.46 (m, 5H), 7.52 (br s, 1H), 7.71 (s, 1H), 8.04 (s, 1H), 8.19 (s, 1H).

Provenance & Evidence