Ammonia → HCID 57537502, compound

HRID 1693744Notes

Reaction equation

HRID 1693744 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:9](=[O:15])[C:10]([N:12]([CH3:14])[CH3:13])=[O:11])[C:5](F)=[N:6][CH:7]=1.[NH3:16]>C(O)C>[NH2:16][C:5]1[C:4]([C:9](=[O:15])[C:10]([N:12]([CH3:14])[CH3:13])=[O:11])=[CH:3][C:2]([Br:1])=[CH:7][N:6]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 57537465HCID 57537465, compound

Product 1

HCID 57537502HCID 57537502, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(5-Bromo-2-fluoro-pyridin-3-yl)-N,N-dimethyl-2-oxo-acetamide (948 mg, 3.45 mmol) was treated with saturated ammonia solution in ethyl alcohol (10 mL) in a sealed vial at 50° C. for 1 h. The reaction was complete and the mixture was dried in vacuo and used crude in the next step. MS: m/z 272 (M+H+).

Workup

  1. customthe mixture was dried in vacuo

Sources & evidence

ORD record
ord-9d4ceea7cd01485c96d2ab548c9533b0
Source dataset
uspto-grants-2012_04
Patent number
US08158647B2

Reaction notes

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