Palladium → {4-[3-[3-(4-chloro-benzylamino)-phenyl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][CH:8]1[CH2:9][CH2:10][CH:11]([NH:14][c:15]2[n:16][cH:17][c:18]3[c:19]([n:20]2)[n:21]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:36])([CH3:37])[CH3:38])[n:22][c:23]3-[c:24]2[cH:25][c:26]([Br:30])[cH:27][cH:28][cH:29]2)[CH2:12][CH2:13]1)=[O:39].[CH2:49]1[O:50][CH2:51][CH2:52][O:53][CH2:54]1.[Cl:40][c:41]1[cH:42][cH:43][c:44]([CH2:45][NH2:46])[cH:47][cH:48]1.[O:57]=[C:58]([CH:59]=[CH:60][c:61]1[cH:62][cH:63][cH:64][cH:65][cH:66]1)[CH:67]=[CH:68][c:69]1[cH:70][cH:71][cH:72][cH:73][cH:74]1.[O:75]=[C:76]([CH:77]=[CH:78][c:79]1[cH:80][cH:81][cH:82][cH:83][cH:84]1)[CH:85]=[CH:86][c:87]1[cH:88][cH:89][cH:90][cH:91][cH:92]1.[O:93]=[C:94]([CH:95]=[CH:96][c:97]1[cH:98][cH:99][cH:100][cH:101][cH:102]1)[CH:103]=[CH:104][c:105]1[cH:106][cH:107][cH:108][cH:109][cH:110]1.[Pd:55].[Pd:56]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][CH:8]1[CH2:9][CH2:10][CH:11]([NH:14][c:15]2[n:16][cH:17][c:18]3[c:19]([n:20]2)[n:21]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:36])([CH3:37])[CH3:38])[n:22][c:23]3-[c:24]2[cH:25][c:26]([NH:46][CH2:45][c:44]3[cH:43][cH:42][c:41]([Cl:40])[cH:48][cH:47]3)[cH:27][cH:28][cH:29]2)[CH2:12][CH2:13]1)=[O:39]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-83abce12cfef4583ae70910b7ef9df58
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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