Water → 3-Amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester

HRID 1694253Notes

Reaction equation

HRID 1694253 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:23])[CH2:5][CH:6]([NH2:22])[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH:14]([F:16])[F:15])=[C:9]([O:17][CH2:18][CH:19]2[CH2:21][CH2:20]2)[CH:8]=1.O.C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)Cl>[CH3:2][O:3][C:4](=[O:23])[CH2:5][CH:6]([NH2:22])[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH:14]([F:15])[F:16])=[C:9]([O:17][CH2:18][CH:19]2[CH2:20][CH2:21]2)[CH:8]=1

Participants

5

Reactant 3

HCID 962WaterHCID 10340Sodium CarbonateHCID 669202293-amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester HCl salt

Product 1

HCID 588000783-Amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester HCl salt (540 mg 1.5 mmol) in methylene chloride (20 ml) was added water (20 ml) and sodium carbonate (160 mg, 1.5 mmol). The mixture was stirred at room temperature for 30 min then separated in separatory funnel. The organic layer was washed with water (20 ml), brine (20 ml) and dried over magnesium sulfate. The solvent was removed in vacuo. The resulted oil was used in next step without further purification.

Workup

  1. customthen separated in separatory funnel
  2. washThe organic layer was washed with water (20 ml), brine (20 ml)
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent was removed in vacuo
  5. customThe resulted oil was used in next step without further purification

Sources & evidence

ORD record
ord-e272828105184341a35bdf259799a8f2
Source dataset
uspto-grants-2012_04
Patent number
US08158672B2

Reaction notes

Loading…