HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4-Chloro-thiobenzoic acid hydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | S-[p-Chlorothiobenzoyl]thioglycolic acid | HCID 593395 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 4-Chloro-thiobenzoic acid hydrazide | HCID 12477075 | — |
Reaction Steps
To a mixture of (4-chloro-thiobenzoylsulfanyl)-acetic acid (8.31 mmol) in 9 mL of NaOH (1N) is added hydrazine hydrate (36.7 mL). Glacial acetic acid (2.7 mL) is then added to the solution and the mixture is vigorously stirred. The reaction mixture is diluted with CH2Cl2 and the organic layer dried over MgSO4 to yield 4-chloro-thiobenzoic acid hydrazide: LC/MS (ES+) 186.9 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158662B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-b99cc83e1a414d7ba05bd1fbf75332dc |
| Source note | uspto-grants-2012_04 |