HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1694377Generated: October 25, 2026
3,4-Dichlorobenzyl chloride → HCID 67279905, compound
https://huagongshe.com/reaction/1694377
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3,4-Dichlorobenzyl chloride | HCID 7609 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methyl 4-(1-(indoline-7-carboxamido)cyclopropyl)benzoate | HCID 58017568 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 67279905 | HCID 67279905 | — |
Reaction Steps
Methyl 4-{1-[(2,3-dihydro-1H-indol-7-ylcarbonyl)amino]cyclopropyl}benzoate (110 mg, 0.327 mmol) was dissolved in acetonitrile (1.3 ml). 3,4-dichlorobenzyl chloride (136 ul. 0.981 mmol), DIPEA (171 ul, 0.981 mmol) and a crystal of TBAI were added. The mixture stirred at 70° C. for 2 h. The solvent was removed. Purification on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08158671B2 |
|---|
| Source dataset | uspto-grants-2012_04 |
|---|
| ORD ID | ord-fb2d5da43db0482c9200fd82dc129222 |
|---|
| Source note | uspto-grants-2012_04 |
|---|
