huagongshe.com
HRID1694436

反应详情

EQUATION

反应方程式

HRID 1694436 的结构方程式

REACTANTS

反应物

1
结构：C[C@H]1CC[C@H](C(=O)N(c2cc(C3=CCCCC3)sc2C(=O)O)[C@H]2CC[C@H](O)CC2)CC1
HCID178461274

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H]1CC[C@H](C(=O)N(c2cc(C3CCCCC3)sc2C(=O)O)[C@H]2CC[C@H](O)CC2)CC1
HCID178461276

未命名化合物

收率 32%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of 5-cyclohex-1-enyl-3-[(trans-4-hydroxy-cyclohexyl)-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid (22 mg, 0.05 mmol) in dry MeOH (1 ml) was added 10% palladium on charcoal (3 mg). The resulting reaction mixture was placed under H2 atmosphere, stirred at room temperature for 16 h, and then filtered on celite and evaporated to dryness. The crude product was purified by flash chromatography using CH2Cl2:MeOH hexanes as eluent to give 5-cyclohexyl-3-[(trans-4-hydroxy-cyclohexyl)-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid (7 mg, 32%).

WORKUP

后处理

  1. customThe resulting reaction mixture
  2. filtrationfiltered on celite
  3. customevaporated to dryness
  4. customThe crude product was purified by flash chromatography