3-Hydroxyazetidine → 1-[2-(4-Chloro-phenyl)-ethyl]-4-(3-hydroxy-azetidine-1-carbonyl)-1H-benzoimidazole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide

HRID 169449Notes

Reaction equation

HRID 169449 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][CH2:9][n:10]2[c:11]([C:22]([NH:23][CH:24]3[CH2:25][CH2:26][N:27]([CH:30]([CH3:31])[CH3:32])[CH2:28][CH2:29]3)=[O:33])[n:12][c:13]3[c:14]2[cH:15][cH:16][cH:17][c:18]3[C:19](=[O:20])[OH:21])[cH:6][cH:7]1.[OH:34][CH:35]1[CH2:36][NH:37][CH2:38]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][CH2:9][n:10]2[c:11]([C:22]([NH:23][CH:24]3[CH2:25][CH2:26][N:27]([CH:30]([CH3:31])[CH3:32])[CH2:28][CH2:29]3)=[O:33])[n:12][c:13]3[c:14]2[cH:15][cH:16][cH:17][c:18]3[C:19](=[O:21])[N:37]2[CH2:36][CH:35]([OH:34])[CH2:38]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 15142903-HydroxyazetidineHCID 670123531-[2-(4-Chloro-phenyl)-ethyl]-2-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-benzoimidazole-4-carboxylic acid

Product 1

HCID 670119391-[2-(4-Chloro-phenyl)-ethyl]-4-(3-hydroxy-azetidine-1-carbonyl)-1H-benzoimidazole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide

Sources & evidence

ORD record
ord-4b9c784035564389bb0ec97ff94852bf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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