2,4-Di-tert-butylphenol → HCID 57533182, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2,4-di-tert-butylphenol (20.6 g, 0.1 mol) in dry THF (50 mL) is added with stirring to a suspension of NaH (2.4 g, 0.1 mol) in dry THF (150 mL). After 1 h of stirring, the mixture is cooled to 0° C., and chloromethyl methyl ether (7.6 mL, 0.1 mol) is added. The reaction mixture is stirred at room temperature for 2 h, quenched with water (500 mL) and extracted with Et2O (2×100 mL). The combined organic phase is dried over MgSO4 and evaporated under reduced pressure. The residue is used for the next step without purification.

Provenance & Evidence