Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 67122522 | HCID 67122522 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ciclesonide | HCID 6918155 | 101.7% |
Reaction Steps
Ciclesonide methanol solvate 100 gms (Form C) was suspended in 1.0 lt. of water and the suspension was stirred and heated at 50 to 60° C. for 2 hrs. The suspension was cooled to 25 to 30° C. The solid was filtered and washed with water and dried under vacuum at 90° C. for 6 hrs. to obtain 96 gms of anhydrous crystalline ciclesonide (Form A).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08158780B2 |
|---|
| Source dataset | uspto-grants-2012_04 |
|---|
| ORD ID | ord-05cc128cd857428c9ba6370b39f03e7e |
|---|
| Source note | uspto-grants-2012_04 |
|---|
