2-[(1R)-1-Chloroethyl]-5-fluoropyridine → HCID 25064754, compound

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Reaction Steps

The title compound was prepared by General method A starting from (2R)-2-[(2-amino-5-mercapto[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol (550 mg, 1.8 mmol) and 2-[(1R)-1-chloroethyl]-5-fluoropyridine (0.46 g, 2.9 mmol). The product was purified by flash column chromatography followed by preparative HPLC (Column: Reprosil, eluent isopropanol:heptane 20:80, flow: 16 mL/min) collecting the first eluting isomer, to yield 135 mg (18% yield) of the title compound.

Provenance & Evidence