反应详情

To the solution of (R)-N-(pyrrolidin-3-yl)isoquinolin-5-amine in isopropyl acetate (5.0 mL, 65 mg/mL by HPLC, from Example 3) was added 6.1 mL of 0.25 M fumaric acid in ethanol. The mixture was stirred until a slurry was formed. The suspension was filtered, washed with ethanol, and dried in a vacuum oven at 60° C. (R)-N-(pyrrolidin-3-yl)isoquinolin-5-amine fumaric acid salt was obtained as a yellow solid (440 mg, 84% yield).

1. customwas formed
2. filtrationThe suspension was filtered
3. washwashed with ethanol
4. dry with materialdried in a vacuum oven at 60° C. (R)-N-(pyrrolidin-3-yl)isoquinolin-5-amine fumaric acid salt