L-Tartaric acid → HCID 44594314, compound

Participants

Reaction Steps

Crude (R)-2-(3-((3-(isoquinolin-5-ylamino)pyrrolidin-1-yl)methyl)phenoxy)ethanol (1.0 g, 2.7 mmol, from example 11) was dissolved in 11 mL of ethanol. The solution was stirred while 27.5 mL of a 0.1 M solution of L-tartaric acid in ethanol was added. After 2 hours, the resulting suspension was filtered, washed with ethanol, and dried under nitrogen. Approximately 1.1 g of (R)-2-(3-((3-(isoquinolin-5-ylamino)pyrrolidin-1-yl)methyl)phenoxy)ethanol L-tartaric acid salt was isolated as a yellow solid (79% yield).

Provenance & Evidence