4-Iodophenol → HCID 67279307, compound

Participants

Reaction Steps

Compound 1 (5.0 g, 8.67 mmol), 4-iodophenol (2.10 g, 9.54 mmol) and triphenyl phosphine (2.5 g, 9.5 mmol) were dissolved in dry THF (35 mL). Diisopropyl azodicarboxylate (1.88 mL, 9.5 mmol) was added dropwise during 15 min, and the reaction was allowed to proceed overnight at RT. All volatiles were removed in vacuo. Purification on silica gel (eluent, petroleum ether, bp 40-60° C.: dichloromethane, 1:1, v/v) yielded 6.07 g of the title compound. 1H NMR (CDCl3): 7.49 (2H, d, J 9.1); 7.37-7.21 (30H); 6.62 (2H, d, J 9.1). 4.43 (1H, m); 3.40 (4H, m).

Provenance & Evidence