Boron tribromide → 3-(4-Hydroxyphenyl)-7-(2-hydroxy-3-phenylpropoxy)chromen-4-one

HRID 1694663Notes

Reaction equation

HRID 1694663 reaction equation
[OH:1][CH:2]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH2:3][O:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:23])[C:10]([C:15]3[CH:20]=[CH:19][C:18]([O:21]C)=[CH:17][CH:16]=3)=[CH:11][O:12]2)=[CH:7][CH:6]=1.B(Br)(Br)Br>>[OH:21][C:18]1[CH:17]=[CH:16][C:15]([C:10]2[C:9](=[O:23])[C:8]3[C:13](=[CH:14][C:5]([O:4][CH2:3][CH:2]([OH:1])[CH2:24][C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)=[CH:6][CH:7]=3)[O:12][CH:11]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 672797737-(2-Hydroxy-3-phenylpropoxy)-3-(4-methoxyphenyl)chromen-4-one

Product 1

HCID 596606453-(4-Hydroxyphenyl)-7-(2-hydroxy-3-phenylpropoxy)chromen-4-one

Procedure

The product of step 1 was then reacted with boron tribromide as shown in Example 16, step 3, to provide 3-(4-hydroxyphenyl)-7-(2-hydroxy-3-phenylpropoxy)chromen-4-one.

Sources & evidence

ORD record
ord-7681c1586b99450c99fa155236a474ef
Source dataset
uspto-grants-2012_04
Patent number
US08158810B2

Reaction notes

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