反应详情

A mixture of the product from step (i) (2 g), 4-(ethylthio)phenylboronic acid (1.5 g), cesium fluoride (2 g) and Pd(dppf)Cl2 (0.2 g) in dioxane (40 ml) was heated under reflux for 3 h. After cooling the mixture was partitioned between diethylether and water. The organics were separated, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 5% EtOAc/iso-hexane. Yield 0.92 g

1. temperaturewas heated
2. temperatureunder reflux for 3 h
3. temperatureAfter cooling the mixture
4. customwas partitioned between diethylether and water
5. customThe organics were separated
6. customdried
7. customevaporated under reduced pressure
8. customThe residue was purified by chromatography on silica eluting with 5% EtOAc/iso-hexane