HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → {[5-Chloro-4'-(ethylthio)biphenyl-2-yl]oxy}acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl {[5-chloro-4'-(ethylthio)biphenyl-2-yl]oxy}acetate | HCID 86609213 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | {[5-Chloro-4'-(ethylthio)biphenyl-2-yl]oxy}acetic acid | HCID 11163081 | — |
Reaction Steps
The title compound was prepared by stirring a mixture of the product from step (ii) (0.3 g) and trifluoroacetic acid (4 ml) in DCM (10 ml) at RT for 5 h. The solvent was evaporated under reduced pressure, the residue triturated with diethylether then purified by reverse phase HPLC. Yield 0.106 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158820B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-38685364f43447d9b553ecdadb2461d0 |
| Source note | uspto-grants-2012_04 |