4-Cyanophenylboronic acid → tert-Butyl [(5-chloro-4'-cyanobiphenyl-2-yl)oxy]acetate

HRID 1694684Notes

Reaction equation

HRID 1694684 reaction equation
[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1Br)([CH3:4])([CH3:3])[CH3:2].[C:18]([C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1)#[N:19]>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:17])=[C:10]([C:23]2[CH:24]=[CH:25][C:20]([C:18]#[N:19])=[CH:21][CH:22]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 27343264-Cyanophenylboronic acidHCID 49766393tert-Butyl (2-bromo-4-chlorophenoxy)acetate

Product 1

HCID 86609214tert-Butyl [(5-chloro-4'-cyanobiphenyl-2-yl)oxy]acetate

Procedure

The subtitle compound was prepared by the method of example 1 step (ii) using the product from example 1 step (i) and 4-cyanophenylboronic acid. Yield 0.524 g

Sources & evidence

ORD record
ord-014ea783aeed4a1e970d11016ff8313d
Source dataset
uspto-grants-2012_04
Patent number
US08158820B2

Reaction notes

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