8-Quinolineboronic acid → tert-Butyl (4-chloro-2-quinolin-8-ylphenoxy)acetate

HRID 1694686Notes

Reaction equation

HRID 1694686 reaction equation
[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1Br)([CH3:4])([CH3:3])[CH3:2].[N:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][C:26]=2B(O)O)[CH:21]=[CH:20][CH:19]=1>>[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:26]1[CH:25]=[CH:24][CH:23]=[C:22]2[C:27]=1[N:18]=[CH:19][CH:20]=[CH:21]2)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27343808-Quinolineboronic acidHCID 49766393tert-Butyl (2-bromo-4-chlorophenoxy)acetate

Product 1

HCID 86006173tert-Butyl (4-chloro-2-quinolin-8-ylphenoxy)acetate

Procedure

The subtitle compound was prepared by the method of example 1 step (ii) using the product from example 1 step (i) and 8-quinoline boronic acid. Yield 0.356 g

Sources & evidence

ORD record
ord-38821313dbbe46b08a033784b5fb6058
Source dataset
uspto-grants-2012_04
Patent number
US08158820B2

Reaction notes

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