Sodium Iodide → 2-Iodo-4-(trifluoromethyl)phenol

Participants

Reaction Steps

Sodium iodide (3.32 g) then chloramine-T (5.91 g) were added to a stirred solution of 4-trifluoromethylphenol (3.0 g) in DMF (30 ml) at O° C. The mixture was warmed to RT, stirred for 1 h, diluted with dilute hydrochloric acid then extracted with diethylether. The organic layer was washed with aqueous sodium thiosulphate solution, dried and the solvent removed under reduced pressure. Yield 5.25 g

Provenance & Evidence