Benzyl Bromide → 1-(Benzyloxy)-2-bromo-4-chlorobenzene

Participants

Reaction Steps

Benzyl bromide (13.1 ml) was added to a stirred mixture of 2-bromo-4-chlorophenol (20.7 g) and potassium carbonate (27.6 g) in DMF (200 ml). After 72 h, the mixture was partitioned between diethylether and water, the organic layer washed with water, dried and the solvent evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 2% EtOAc/isohexane. Yield 18.1 g

Provenance & Evidence