5-Bromo-2-chloropyrimidine → HCID 86006111, compound

HRID 1694699Notes

Reaction equation

HRID 1694699 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1B(O)O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:19][C:20]1[N:25]=[CH:24][C:23](Br)=[CH:22][N:21]=1>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:23]1[CH:22]=[N:21][C:20]([Cl:19])=[N:25][CH:24]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6066655-Bromo-2-chloropyrimidineHCID 41987402-Benzyloxy-5-chlorobenzeneboronic acid

Product 1

HCID 86006111HCID 86006111, compound

Procedure

The subtitle compound was prepared by the method of example 1 step (ii) using the product from example 16 step (ii) (3.2 g) and 2-chloro-5-bromopyrimidine (2.59 g). Yield 2.43 g

Sources & evidence

ORD record
ord-12686631549e42bd9cfb5021c92aaf06
Source dataset
uspto-grants-2012_04
Patent number
US08158820B2

Reaction notes

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